5-Amino-4-cyanopyrazole → 6-Methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 345940

Reaction equation

HRID 345940 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]#[N:8].C(O[CH:12]=[C:13]([CH3:16])[CH:14]=O)C>>[CH3:16][C:13]1[CH:12]=[N:1][C:2]2[N:6]([N:5]=[CH:4][C:3]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 855155-Amino-4-cyanopyrazoleHCID 5591983-Ethoxy-2-methyl-2-propenal

Product 1

HCID 150420806-Methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Procedure

By the procedure described in Example 2, 5.40 g of 5-amino-4-pyrazolecarbonitrile is reacted with 5.70 g of 3-ethoxy-2-methylacrolein in 25 ml of glacial acid to give the desired product as colorless prisms, mp 193°-194° C.

Sources & evidence

ORD record
ord-04ca890444c0418aa03cb4be0391b94c
Source dataset
uspto-grants-1991_10
Patent number
US05059691

Linked notes

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