Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10].[C:11]([O:14][CH:15](OC(=O)C)[C:16]([CH3:18])=[CH2:17])(=[O:13])[CH3:12]>>[C:11]([O:14][CH:15]=[C:16]([CH3:18])[CH2:17][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]([O:9][CH3:10])[CH:5]=1)(=[O:13])[CH3:12]Participants
3
Conditions
- Temperature
- 22.5 °C
Procedure
In an argon gas atmosphere, a three necked flask having a capacity of 25 ml was charged with 13.82 g (100 m moles) of 1,2-dimethoxybenzene and 1.87 g (10 m moles) of 3,3-diacetoxy-2-methylpropene having a purity degree of 92.0% by mass. Then, the resultant mixture was mixed with 0.142 g (1 m mole) of boron trifluoride-ether complex at an internal temperature of 18 to 19° C. The mixture was stirred at an internal temperature of 22 to 23° C. for 2 hours. After the reaction was completed, the resultant reaction liquid was subjected to a quantitative analysis using a high performance liquid chromatography. In the result, the target 1-acetoxy-2-methyl-3-(3,4-dimethoxyphenyl)propene was obtained in a yield of 94.4% (amount: 2.36 g).
Workup
- customthe resultant reaction liquid
Sources & evidence
- ORD record
- ord-a3494a84ee134c11a5b201ead8858237
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07173148B2
Linked notes
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