Hydrochloric Acid → Sertraline Hydrochloride

Participants

Reaction Steps

A solution of 50.8 g free sertraline base in 100 ml of n-hexanol was added dropwise over a period of about 30 minutes at room temperature onto 100 ml of n-hexanol containing 14 ml of 37% aqueous hydrochloric acid. About ¾ of the way through the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 49.5 g of sertraline hydrochloride form II are obtained in a yield of 87%.

Provenance & Evidence