Hydrochloric Acid → Sertraline Hydrochloride

Participants

Reaction Steps

A solution of 53 g free sertraline base in 100 ml of n-octanol was added dropwise over a period of about 30 minutes at room temperature onto 100 ml of n-octanol containing 15 ml of 37% aqueous hydrochloric acid. About half way through the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 53.4 g of sertraline hydrochloride form II are obtained with a yield of 90%.

Provenance & Evidence