2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl- → 1-Ethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Reaction equation

[CH2:1]([N:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][CH2:6][CH2:5][C:4]1=O)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([N:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][CH2:6][CH2:5][CH2:4]1)[CH3:2]

Participants

Reactant 2

HCID 30782002H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

HCID 21226445Aluminium lithium hydride

Product 1

HCID 196082311-Ethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Procedure

1-Ethyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine from Example 23A (1.7 g, 8.94 mmol) was reduced with lithium aluminium hydride according to the procedure in Example 15A; yield 1.55 g (98%).

Sources & evidence

ORD record: ord-22f1219c5951471885c126a5b9c5d9f4
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176195B2

Reaction notes

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