3-Pyridineacetonitrile → 6-Pyridin-3-yl-pyrido[2,3-d]pyrimidine-2,7-diamine

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1.[NH2:10][C:11]1[N:16]=[C:15]([NH2:17])[C:14]([CH:18]=O)=[CH:13][N:12]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8]([NH2:9])=[N:17][C:15]3[N:16]=[C:11]([NH2:10])[N:12]=[CH:13][C:14]=3[CH:18]=2)[CH:2]=1

Participants

Reactant 2

HCID 809233-Pyridineacetonitrile

HCID 3091762,4-Diaminopyrimidine-5-carbaldehyde

Product 1

HCID 218500626-Pyridin-3-yl-pyrido[2,3-d]pyrimidine-2,7-diamine

Procedure

The procedure of Example 1 was followed to react 3-pyridylacetonitrile and 2,4-diamino-5-pyrimidine-carboxaldehyde to afford the title compound; mp 317°-319° C. (dec).

Sources & evidence

ORD record: ord-4a76dcd362764370a4ab0d70f23633f8
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05733913

Reaction notes

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