2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → 2,4-Diamino-6-(5-aminopentyl)-1,3,5-triazine

HRID 34783

Reaction equation

HRID 34783 reaction equation
[NH2:1][C:2]([NH:4][C:5]([NH2:7])=[NH:6])=[NH:3].CO[C:10]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][N:11]=1>C(O)C>[NH2:6][C:5]1[N:4]=[C:2]([NH2:1])[N:3]=[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:10][NH2:11])[N:7]=1

Participants

4

Reactant 2

HCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-HCID 176517607Carbamimidamidomethanimidamide

Product 1

HCID 212987902,4-Diamino-6-(5-aminopentyl)-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of biguanide (1.05 g.), 4,5,6,7-tetrahydro-2-methoxy-3H-azepine (1.27 g.) and ethanol (50 ml.) was heated under reflux for 18 hours, cooled and the solid that crystallised was collected to give 2,4-diamino-6-(5-aminopentyl)-1,3,5-triazine which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. temperaturecooled
  4. customthe solid that crystallised
  5. customwas collected

Sources & evidence

ORD record
ord-d160538931fd480d9675ac1086279244
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Linked notes

Loading…