Ammonia → HCID 178512201, compound

HRID 34825

Reaction equation

HRID 34825 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=S)[CH:6]=[CH:7][CH:8]=1.[NH3:18]>>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[NH:18])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 212987211-(3-Hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)thiourea

Product 1

HCID 178512201HCID 178512201, compound

Procedure

The above thiourea (1.32 g.) was stirred in 1.6N alcoholic ammonia (50 ml.) with mercuric oxide (3.4 g.) for 17 hours at 20°. The resulting mixture was clarified on the centrifuge and the supernatant was evaporated in vacuo to a syrup which was further dried at 70°/0.1 m.m. to give 1-(3-hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine. The n.m.r. spectrum in d6 dimethylsulphoxide using tetramethyl silane as internal standard (δ=0) had the following resonances (δ): 6.9 (4H, multiplet); 4.4 (2H, singlet); 3.9 (2H, quartet).

Workup

  1. customthe supernatant was evaporated in vacuo to a syrup which
  2. customwas further dried at 70°/0.1 m

Sources & evidence

ORD record
ord-00c69c864a8d46f2b45b9e7a83fcad2d
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Linked notes

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