1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde
Reaction equation
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.
Workup
- filtrationThe reaction solution was filtrated through Celite
- distillationthe solvent was then distilled off
- customThe residue was dried under vacuum
Sources & evidence
- ORD record
- ord-08bcf8622f984d33a60644c8f0c66571
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07176227B2
Reaction notes
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