Thionyl Chloride → 4-Oxo-3-thiazolidinylacetyl chloride

Participants

Reaction Steps

Thionyl chloride (2.00 ml) was added dropwise to a solution of 4-oxo-3-thiazolidinylacetic acid (1.60 g) in a mixture of dichloromethane (20 ml) and tetrahydrofuran (5.0 ml) at room temperature. After the mixture was stirred for 5 hours at the same temperature, the solvent was evaporated in vacuo to give 4-oxo-3-thiazolidinylacetyl chloride (1.78 g) as brown semisolid.

Provenance & Evidence