Thionyl Chloride → 5-Bromofuran-2-carbonyl chloride

HRID 34945

Reaction equation

HRID 34945 reaction equation
[Br:1][C:2]1[O:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1>[Br:1][C:2]1[O:6][C:5]([C:7]([Cl:12])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 685115-Bromo-2-furanecarboxylic acid

Product 1

HCID 27570115-Bromofuran-2-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

21.0 g of 5-bromo-2-furancarboxylic acid were suspended in 650 ml of toluene and 40 ml of thionyl chloride and the suspension was heated to reflux for 2 hours. The reaction solution was thereafter concentrated, whereby 5-bromo-2-furancarboxylic acid chloride was obtained as the residue.

Workup

  1. temperatureto reflux for 2 hours
  2. concentrationThe reaction solution was thereafter concentrated

Sources & evidence

ORD record
ord-374bfbb4f33346df9af44276ccb38c16
Source dataset
uspto-grants-1988_08
Patent number
US04764522

Linked notes

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