5-Bromonicotinonitrile → 5-(5-Bromo-3-pyridyl)-1H-tetrazole

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:10]1C=N[N:12]=[N:11]1>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:7]2[N:10]=[N:11][NH:12][N:8]=2)[CH:9]=1

Participants

Reactant 2

HCID 7367935-Bromonicotinonitrile

HCID 178418441HCID 178418441, compound

Product 1

HCID 41737615-(5-Bromo-3-pyridyl)-1H-tetrazole

Procedure

5-Bromo-nicotinonitrile (10.0 g, 55 mmol) was converted to the corresponding tetrazole (10.8 g, 75%) using the reaction conditions previously described in Step (a) of Example 1. 1H NMR (DMSO-d6) δ 9.17 (s, 1H), 8.89 (2, 1H), 8.59 (s, 1H).

Workup

customthe reaction conditions

Sources & evidence

ORD record: ord-5dfb94800d034797aae1ccd04d6b2101
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07179822B2

Reaction notes

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