Acrylonitrile → 3-[(Cyclopropylmethyl)amino]propanenitrile
Reaction equation
[C:1](#[N:4])[CH:2]=[CH2:3].[NH2:5][CH2:6][CH:7]1[CH2:9][CH2:8]1>>[CH:7]1([CH2:6][NH:5][CH2:3][CH2:2][C:1]#[N:4])[CH2:9][CH2:8]1Participants
3
Procedure
With stirring and cooling in an ice-bath to maintain a temperature of 8–10° C., acrylonitrile (0.614 ml) was added to aminomethylcyclopropane (0.651 g). The resultant mixture was stirred at room temperature for 15 h to give the title compound (1.02 g) as a yellow oil.
Workup
- temperaturecooling in an ice-bath
Sources & evidence
- ORD record
- ord-b67c1ed0828f468a8f1f407676f3a4bf
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07179835B2
Reaction notes
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