6-Bromohexanoic acid → 6-[2-(2-Hydroxyethyl)-3,4dichlorophenoxy]hexanoic acid

Reaction equation

[OH:1][CH2:2][CH2:3][C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[OH:12].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>>[OH:1][CH2:2][CH2:3][C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[O:12][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]

Participants

Reactant 2

HCID 202106-Bromohexanoic acid

HCID 212972712-(2-Hydroxyethyl)-3,4-dichlorophenol

Product 1

HCID 212972646-[2-(2-Hydroxyethyl)-3,4dichlorophenoxy]hexanoic acid

Procedure

Following the procedure of Example 1C, two millimoles each of 2-(2-hydroxyethyl)-3,4-dichlorophenol and 6-bromohexanoic acid were reacted to provide 55 mg. of the desired title product which crystallized from methylene chloride.

Workup

customwere reacted
customto provide 55 mg
customof the desired title product which crystallized from methylene chloride

Sources & evidence

ORD record: ord-a60bf8aa8a5740c6b9c6e472f2095888
Source dataset: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04764521

Reaction notes

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