(4-Cyano-3-fluoro-phenoxy)-acetic acid methyl ester → Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate

HRID 350979

Reaction equation

HRID 350979 reaction equation
[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[C:8]([F:14])[CH:7]=1.C(OC(=O)C(OC1C=CC(C#N)=C(F)C=1)C)(C)(C)C>>[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[C:8]([F:14])[CH:7]=1

Participants

3

Reactant 2

HCID 23529353(4-Cyano-3-fluoro-phenoxy)-acetic acid methyl esterHCID 235293652-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester

Product 1

HCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate

Procedure

The compound of Formula (5.0.19) was prepared in a manner analogous to that described in Preparation 10, substituting (4-cyano-3-fluoro-phenoxy)-acetic acid methyl ester for the corresponding 2-(4-cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester material.

Workup

  1. customthat described in Preparation 10

Sources & evidence

ORD record
ord-449755305d3f41b08bd8bc95d22deba1
Source dataset
uspto-grants-2007_02
Patent number
US07183293B2

Linked notes

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