(+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester → HCID 10115978, compound

HRID 351000

Reaction equation

HRID 351000 reaction equation
C([O:5][C:6](=[O:37])[CH:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]([C:20]2[C:21]([O:26][C:27]3[CH:35]=[CH:34][C:30]4=[N:31][S:32][N:33]=[C:29]4[CH:28]=3)=[N:22][CH:23]=[CH:24][CH:25]=2)=[O:19])=[C:12]([F:36])[CH:11]=1)[CH3:8])(C)(C)C.C(OC(=O)C(OC1C=CC(CNC(C2C(OC3C=CC4=NON=C4C=3)=NC=CC=2)=O)=C(F)C=1)C)(C)(C)C>>[N:31]1[S:32][N:33]=[C:29]2[CH:28]=[C:27]([O:26][C:21]3[C:20]([C:18]([NH:17][CH2:16][C:13]4[CH:14]=[CH:15][C:10]([O:9][CH:7]([CH3:8])[C:6]([OH:37])=[O:5])=[CH:11][C:12]=4[F:36])=[O:19])=[CH:25][CH:24]=[CH:23][N:22]=3)[CH:35]=[CH:34][C:30]=12

Participants

3

Reactant 2

HCID 23529359(+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl esterHCID 23529360(+)-2-[4-({[2-(Benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester

Product 1

HCID 10115978HCID 10115978, compound

Procedure

The compound of Formula (5.5.7) was prepared in a manner analogous to that described in Example 3, substituting (+)-2-[4-({[2-(benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester for the corresponding (±)-2-[4-({[2-(benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro -phenoxy]-propionic acid tert-butyl ester material.

Sources & evidence

ORD record
ord-fe38f03f16fd4063a98056ba93afe392
Source dataset
uspto-grants-2007_02
Patent number
US07183293B2

Linked notes

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