Bromine → 3-(2-Bromoacetyl)-4-hydroxybenzoic acid
Reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[OH:13])[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[Br:14]Br>C(O)(=O)C>[Br:14][CH2:2][C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[OH:13])[C:7]([OH:9])=[O:8])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
The compound obtained in Step A (32.2 mmol) is dissolved in glacial acetic acid (40 ml) and then 48.3 mmol of bromine are added. The mixture is heated at 80° C. for 2 hours and is then hydrolysed using ice-cold water. The precipitate obtained is filtered off, washed with water until a pH of 5–6 is obtained, and then dried and recrystallised.
Workup
- customThe precipitate obtained
- filtrationis filtered off
- washwashed with water until a pH of 5–6
- customis obtained
- customdried
- customrecrystallised
Sources & evidence
- ORD record
- ord-add10a4568164949bbc2892533785436
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07183318B2
Reaction notes
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