Methyl iodide → 3-Chloro-4-methoxybenzaldehyde

HRID 351818Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[CH3:11]I>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 170223-Chloro-4-hydroxybenzaldehyde

Product 1

HCID 786193-Chloro-4-methoxybenzaldehyde

Procedure

Following a similar procedure to that described in reference example 3, but starting from 3-chloro-4-hydroxybenzaldehyde instead of 4-hydroxybenzaldehyde and using methyl iodide instead of 2-iodopropane, the title compound of the example was obtained as an oil (97% yield).

Sources & evidence

ORD record: ord-b19d5550f50d41b9a4916cf26558f8d2
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06743816B2

Reaction notes

Loading…