cis-1-Benzyl-2,6-dimethylpiperazine → cis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindoline

HRID 352358

Reaction equation

HRID 352358 reaction equation
[CH2:1]([N:8]1[C@H:13]([CH3:14])[CH2:12][NH:11][CH2:10][C@@H:9]1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16]([N:19]1[C:27]2[C:22](=[CH:23][C:24]([O:29][CH3:30])=[C:25](Br)[CH:26]=2)[CH2:21][CH2:20]1)(=[O:18])[CH3:17]>>[C:16]([N:19]1[C:27]2[C:22](=[CH:23][C:24]([O:29][CH3:30])=[C:25]([N:11]3[CH2:12][C@H:13]([CH3:14])[N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[C@H:9]([CH3:15])[CH2:10]3)[CH:26]=2)[CH2:21][CH2:20]1)(=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 12284911cis-1-Benzyl-2,6-dimethylpiperazineHCID 219483751-Acetyl-6-bromo-5-methoxyindoline

Product 1

HCID 69835917cis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindolineYield 43%

Procedure

The title compound was prepared in 43% yield from cis-1-benzyl-2,6-dimethylpiperazine (Org. Prep. Proc. 1976, 8, 19) and D1 using a similar procedure to Description 2.

Sources & evidence

ORD record
ord-1c4b6323778248b68d7c9c0145e012b0
Source dataset
uspto-grants-2004_06
Patent number
US06747030B1

Linked notes

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