Thiourea → 2-Amino-4-(3-bromo-5-isoxazolyl)-thiazole
Reaction equation
Br[CH2:2][C:3]([C:5]1[O:9][N:8]=[C:7]([Br:10])[CH:6]=1)=O.[NH2:11][C:12]([NH2:14])=[S:13]>C(O)C>[NH2:14][C:12]1[S:13][CH:2]=[C:3]([C:5]2[O:9][N:8]=[C:7]([Br:10])[CH:6]=2)[N:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 32.4 g (120.4 mol) of 5-bromoacetyl-3-bromoisoxazole and 18.4 g (240 mmol) of thiourea in 400 ml of anhydrous ethanol was refluxed for 90 minutes.
Workup
- temperaturewas refluxed for 90 minutes
Sources & evidence
- ORD record
- ord-9644ee042c6549bb8ea8936e03738844
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04766137
Reaction notes
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