HCID 20732811, compound → HCID 14863951, compound
Reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1C(OCC1C=CC=CC=1)=O>CCO.[Ni]>[CH3:1][O:2][CH:3]([O:19][CH3:20])[CH:4]1[CH2:8][CH2:7][CH2:6][NH:5]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of acetal 15 (5.8 9, 0.02 mol) in EtOH (50 mL) was allowed to stir for 16 hours at room temperature over Raney nickel (0.2 g), in order to remove the trace amounts of sulphur impurities prior to hydrogenation. Excess nickel was removed by filtration through Celite.
Workup
- customto remove the trace amounts of sulphur impurities
- customExcess nickel was removed by filtration through Celite
Sources & evidence
- ORD record
- ord-5ffbb9d8496a4c7691dc131f96ab5b1a
- Source dataset
- uspto-grants-2004_06
- Patent number
- US06747144B1
Reaction notes
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