2-Amino-5-bromopyridine → 4-(6-Aminopyridin-3-yl)benzoic acid

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[C:9]([C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1)([OH:11])=[O:10]>>[NH2:8][C:5]1[CH:4]=[CH:3][C:2]([C:15]2[CH:16]=[CH:17][C:12]([C:9]([OH:11])=[O:10])=[CH:13][CH:14]=2)=[CH:7][N:6]=1

Participants

Reactant 2

HCID 706222-Amino-5-bromopyridine

HCID 3121834-Carboxyphenylboronic Acid

Product 1

HCID 227099024-(6-Aminopyridin-3-yl)benzoic acid

Procedure

In the same manner as in Example 2, a reaction was conducted using 5-bromo-2-aminopyridine and 4-carboxyphenyboronic acid as starting materials, whereby 4-(2-aminopyridin-5-yl)benzoic acid was obtained.

Sources & evidence

ORD record: ord-773f864c27aa49b98270d64b01e4d645
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06747023B1

Reaction notes

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