Tert-butyl 4-benzylpiperazine-1-carboxylate → 1-Benzylpiperazine hydrochloride

HRID 352777Notes

Reaction equation

HRID 352777 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:21].C(O)C>>[ClH:21].[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 584330Tert-butyl 4-benzylpiperazine-1-carboxylateHCID 21887872Ethanol hydrochloride

Product 1

HCID 27566531-Benzylpiperazine hydrochlorideYield 97%

Procedure

To 1-benzyl-4-tert-butoxycarbonylpiperazine (3.12 g), saturated ethanol hydrochloride was added, followed by stirring for 90 minutes at room temperature. The solvent was distilled off under reduced pressure, followed by drying, whereby the title compound (2.73 g, 97%) was obtained as white powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customby drying

Sources & evidence

ORD record
ord-33705c0319e7456583203d04feae1405
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

Loading…