6-cyanobenzofuran-2-carboxylic Acid → HCID 22709960, compound
Reaction equation
[C:1]([C:3]1[CH:14]=[CH:13][C:6]2[CH:7]=[C:8]([C:10]([OH:12])=O)[O:9][C:5]=2[CH:4]=1)#[N:2].Cl.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)(=[O:29])=[O:28])[CH:21]=[CH:20]2>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:31][CH2:32][N:33]([C:10]([C:8]3[O:9][C:5]4[CH:4]=[C:3]([C:1]#[N:2])[CH:14]=[CH:13][C:6]=4[CH:7]=3)=[O:12])[CH2:34][CH2:35]1)(=[O:28])=[O:29])[CH:21]=[CH:20]2Participants
3
Procedure
In the same manner as in Referential Example 319, a reaction was effected using 6-cyanobenzofuran-2-carboxylic acid and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride as starting materials, whereby the title compound was obtained.
Sources & evidence
- ORD record
- ord-4da129f8704543b983bc398101bd2b89
- Source dataset
- uspto-grants-2004_06