HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Methyl pyrazinoate | HCID 72662 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(2-Hydroxyethyl)pyrazine-2-carboxamide | HCID 14230272 | 80% |
Reaction Steps
A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766125 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-5c89f624e3c24f21936bf0d2ca764d41 |
| Source note | uspto-grants-1988_08 |