3-Pyridylmethyl isothiocyanate → HCID 22707701, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][N:7]=[C:6]2[N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]=[C:28]=[S:29])[CH:21]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][N:7]=[C:6]2[N:14]1[CH2:15][CH2:16][N:17]([C:28](=[S:29])[NH:27][CH2:26][C:22]2[CH:21]=[N:20][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:19]1Participants
3
Procedure
Substantially the same procedure as in Example 1 was repeated, except that 6-methoxy-7-methyl-4-(1-piperazinyl)quinazoline was used in place of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline, and the corresponding 3-picolyl isothiocyanate was used in place of phenyl isocyanate, to give the desired compound.
Sources & evidence
- ORD record
- ord-a03af8628b04488299f3ae3f57aff57c
- Source dataset
- uspto-grants-2004_06