Ethanol → HCID 22708122, compound

HRID 353218

Reaction equation

HRID 353218 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH3:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=O.[OH-].[K+].C(O)C>O>[F:1][C:2]1[CH:3]=[C:4]([C:5](=[O:6])/[CH:10]=[CH:11]/[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 99673-FluoroacetophenoneHCID 14797Potassium HydroxideHCID 680093-Fluorobenzaldehyde

Product 1

HCID 22708122HCID 22708122, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 3-fluorobenzaldehyde (7.63 mL, 72.4 mmol), 3-fluoroacetophenone (10 g, 72.4 mmol), potassium hydroxide (5.18 g, 92.6 mmol), ethanol (23 mL) and water (47 mL) was stirred overnight at room temperature. After the reaction solution was diluted with water, the solid was collected by filtration and washed with ethanol and diethyl ether, to give the title compound (16.4 g, 93%).

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-1dc89752ecc94f6f816c4c7f12c5b1be
Source dataset
uspto-grants-2004_06
Patent number
US06750232B2

Linked notes

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