Sulfuric Acid → Propanamide, 2-hydroxy-2-methyl-

HRID 353371

Reaction equation

[CH3:1][C:2]([CH3:6])([OH:5])[C:3]#[N:4].[S:7](=[O:11])(=[O:10])([OH:9])[OH:8]>>[OH:5][C:2]([CH3:6])([CH3:1])[C:3]([NH2:4])=[O:8].[S:7]([OH:11])([OH:10])(=[O:9])=[O:8].[OH:5][C:2]([CH3:6])([CH3:1])[C:3]([NH2:4])=[O:8]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 6406Acetone Cyanohydrin

Product 2

HCID 83059Propanamide, 2-hydroxy-2-methyl-

HCID 441515422-Hydroxy-2-methylpropanimidic acid--sulfuric acid (1/1)

Procedure

This preparation generally comprises the reaction of acetone cyanohydrin with concentrated sulphuric acid to give α-hydroxyisobutyramide and α-hydroxyisobutyramide sulphate. These two compounds are then heated to give sulphuric methacrylamide.

Workup

customThis preparation

Sources & evidence

ORD record: ord-e208b1e0cb694468a30c1f4c06ed8219
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06750368B2

Linked notes

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