1-Chloro-2-pentyne → (4-Pent-2-ynyloxy-phenylsulfanyl)-acetic acid ethyl ester

HRID 353517

Reaction equation

HRID 353517 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].[CH2:15](Cl)[C:16]#[C:17][CH2:18][CH3:19]>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:15][C:16]#[C:17][CH2:18][CH3:19])=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 897641-Chloro-2-pentyneHCID 3742252Ethyl 2-[(4-hydroxyphenyl)sulfanyl]acetate

Product 1

HCID 11288950(4-Pent-2-ynyloxy-phenylsulfanyl)-acetic acid ethyl ester

Procedure

(4-Pent-2-ynyloxy-phenylsulfanyl)-acetic acid ethyl ester was prepared according to the general method as outlined in Example 1 (Step 2). Starting from (4-hydroxy-phenylsulfanyl)-acetic acid ethyl ester (5 g, 30 mmol) and 2-pentynyl chloride (3.7 g, 36.6 mmol) 7.15 g of the product isolated. Yield 7.15 g (86%); brown oil; MS: 278 EI (M+H)+.

Workup

  1. customisolated

Sources & evidence

ORD record
ord-457da6cdbe504dcfa39327d4fe30e426
Source dataset
uspto-grants-2004_06
Patent number
US06753337B2

Linked notes

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