N,N-Bis(2-chloroethyl)benzylamine hydrochloride → Ethyl 1-benzyl-4-{[3-(2-butynyloxy)phenyl]sulfonyl}-4-piperdine carboxylate

Participants

Reaction Steps

Ethyl 1-benzyl-4-{[3-(2-butynyloxy)phenyl]sulfonyl}4-piperdine carboxylate was prepared according to the general method as outlined in example 1 (step 6), starting from ethyl{[3-(2-butynyloxy)phenyl]sulfonyl}acetate (3 g, 10.1 mmol) and Benzyl-bis-(2-chloro-ethyl) amine hydrochloride (2.88 g, 10.7 mmol); 2.91 g yellow oil. Yield 63%; MS: 456.3 (M+H)+.

Provenance & Evidence