Cyanamide → [4-Amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl](1,3-benzodioxol-5-yl)methanone

HRID 353738

Reaction equation

HRID 353738 reaction equation
[N:1]#[C:2][NH2:3].[N:4]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)=[CH:9][CH:8]=1)=[C:5]=[S:6].[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([C:29](=[O:32])[CH2:30]Br)=[CH:28][C:23]=2[O:22][CH2:21]1>>[NH2:1][C:2]1[N:3]=[C:5]([NH:4][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]3)=[CH:11][CH:12]=2)[S:6][C:30]=1[C:29]([C:27]1[CH:26]=[CH:25][C:24]2[O:20][CH2:21][O:22][C:23]=2[CH:28]=1)=[O:32]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 2437771-(1,3-Dioxaindan-5-yl)-2-bromoethan-1-oneHCID 137183971-(4-Isothiocyanatophenyl)-4-methylpiperazine

Product 1

HCID 10296815[4-Amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl](1,3-benzodioxol-5-yl)methanoneYield 75%

Procedure

This compound was prepared in 75% yield from cyanamide (Aldrich), 1-(4-isothiocyanatophenyl)-4-methylpiperazine (of Example 1), and 1-(1,3-benzodioxol-5-yl)-2-bromoethanone (of Example 11) following the procedure used to in Example 24.

Sources & evidence

ORD record
ord-8cb8764db9a9411bb048e933e5257486
Source dataset
uspto-grants-2004_06
Patent number
US06756374B2

Linked notes

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