Dimethylamine → 2-Aminomethyl-4-(1,1-dimethylethyl)-6-dimethylsulfamoylphenol hydrochloride

Reaction equation

C([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:9]=[C:8]([S:16]([Cl:19])(=[O:18])=[O:17])[C:7]=1[OH:20])(=O)C.[CH3:21][NH:22][CH3:23]>>[ClH:19].[NH2:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:9]=[C:8]([S:16](=[O:18])(=[O:17])[N:22]([CH3:23])[CH3:21])[C:7]=1[OH:20]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 132103492-Acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol

Product 1

HCID 212969282-Aminomethyl-4-(1,1-dimethylethyl)-6-dimethylsulfamoylphenol hydrochloride

Procedure

This compound is prepared analogously to Examples 11 c and 11 d from 2-acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol and dimethylamine.

Sources & evidence

ORD record: ord-4bdfdcf43ae140418427a215492336c1
Source dataset: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04766241

Reaction notes

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