Ammonia → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

HRID 35414Notes

Reaction equation

HRID 35414 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](Cl)(=[O:18])=[O:17])[C:8]=1[OH:20])=[O:4].[NH3:21]>CC(C)=O.O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](=[O:18])(=[O:17])[NH2:21])[C:8]=1[OH:20])=[O:4]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

Product 1

HCID 132103556-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

33.8 g (0.1 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane are dissolved in a little acetone, and the solution is added dropwise to 50 ml of concentrated ammonia solution. The mixture is stirred for 30 minutes at room temperature and is diluted with water. The precipitate which is deposited is filtered off with suction and dissolved in acetone, and the solution is filtered and stirred into water again.

Workup

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. dissolutiondissolved in acetone
  3. filtrationthe solution is filtered
  4. stirringstirred into water again

Sources & evidence

ORD record
ord-d94f91d0f9144c46a22b824f9bf58f64
Source dataset
uspto-grants-1988_08
Patent number
US04766241

Reaction notes

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