4-Fluorobenzylamine → 4-(4-Fluorobenzylamino)-1-methylpiperidine

HRID 354141

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][NH2:15])=[CH:12][CH:11]=1>>[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][NH:15][CH:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 740491-Methyl-4-piperidone

Product 1

HCID 28466454-(4-Fluorobenzylamino)-1-methylpiperidine

Procedure

Starting materials: 1-Methyl-4-piperidone (1.13 g, 10.0 mmol, 1.0 eq.), 4-fluorobenzylamine (1.25 g, 1.0 eq.).

Sources & evidence

ORD record: ord-a7859a25723240d9be2cfce311f3d3d8
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06756393B2

Linked notes

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