HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Amino-4-fluorobutanoic acid hcl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Boc-amino-4-fluorobutanoic acid | HCID 20508340 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Amino-4-fluorobutanoic acid hcl | HCID 86007272 | 68% |
Reaction Steps
4-Fluoro-3-tert-butoxycarbonylamino-1-butanoic acid (545 mg, 2.46 mmoles) is dissolved in dry ether (20 ml) saturated with hydrogen chloride gas. After a few minutes, the solution becomes turbid and white crystals start to precipitate. Recrystallization from ethanol/ether afford beta-monofluoromethyl beta-alanine hydrochloride (265 mg, 68%), m.p. 152°-153° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04375477 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-eed7923475da4476acece2ab9d5f73eb |
| Source note | uspto-grants-1983_03 |