1-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)urea → HCID 20506136, compound

HRID 354749

Reaction equation

HRID 354749 reaction equation
[Br:1][C:2]1[C:7]2[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])=[N:9][C:10]([CH3:16])([CH3:15])[C:11](=[O:14])[N:12]([CH3:13])[C:6]=2[CH:5]=[CH:4][C:3]=1[N:24]=C=O.BrC1C2C(C3C=CC=CC=3Cl)=NC(C)(C)C(=O)N(C)C=2C=CC=1NC(NCCO)=O>CC(C)=O.CCOCC>[NH2:24][C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH3:13])[C:11](=[O:14])[C:10]([CH3:16])([CH3:15])[N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:7]=2[C:2]=1[Br:1]

Participants

4

Reactant 2

HCID 205061371-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)ureaHCID 20506177[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]isocyanate

Product 1

HCID 20506136HCID 20506136, compound

Reagents, catalysts & solvents 1

HCID 21584533Acetone diethyletherSolvent

Procedure

From 4.5 g (0.011 mol) of 7-amino-6-bromo-5-(o-chlorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one there is obtained, in analogy to the details in Example 4, via [6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]isocyanate, 1-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)urea of melting point 214°-218° (acetone/ether).

Sources & evidence

ORD record
ord-79364905c46f4d39a9391a8f70bc829a
Source dataset
uspto-grants-1983_03
Patent number
US04377522

Linked notes

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