HCID 20506156, compound → HCID 20506164, compound

HRID 354751

Reaction equation

HRID 354751 reaction equation
FC1C=CC=CC=1C1C2C=C([N+]([O-])=O)C=CC=2N(C)C(=O)C(C)(C)N=1.[Cl:26][C:27]1[C:37]2[N:36](C)[C:35](=[O:39])[C:34]([CH3:41])([CH3:40])[N:33]=[C:32]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[F:48])[C:31]=2[CH:30]=[C:29]([N+:49]([O-:51])=[O:50])[CH:28]=1>C(O)(C)C.C(Cl)Cl>[Cl:26][C:27]1[C:37]2[NH:36][C:35](=[O:39])[C:34]([CH3:41])([CH3:40])[N:33]=[C:32]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[F:48])[C:31]=2[CH:30]=[C:29]([N+:49]([O-:51])=[O:50])[CH:28]=1

Participants

4

Reactant 2

HCID 20506156HCID 20506156, compoundHCID 20506176HCID 20506176, compound

Product 1

HCID 20506164HCID 20506164, compound

Reagents, catalysts & solvents 1

HCID 21966342Isopropanol methylene chlorideSolvent

Procedure

From 120 g (0.33 mol) of 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one there is obtained, in analogy to the details in paragraph (c) of Example 1, 9-chloro-5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-7-nitro-2H-1,4-benzodiazepin-2-one of melting point 146°-147° (isopropanol/methylene chloride).

Sources & evidence

ORD record
ord-93b7ac5adae9461f9fb77300cecdc5a4
Source dataset
uspto-grants-1983_03
Patent number
US04377522

Linked notes

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