2-Chromanecarbonyl chloride → HCID 20506434, compound

HRID 354822Notes

Reaction equation

HRID 354822 reaction equation
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31](Cl)=[O:32]>CO>[ClH:18].[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:2][CH2:3]1)=[O:32]

Participants

4

Reactant 2

HCID 27945832-Chromanecarbonyl chlorideHCID 20506419HCID 20506419, compound

Product 1

HCID 20506434HCID 20506434, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 0.10 mole of 2-(piperazin-1-yl)-4-amino-6-chloro-7-methoxyquinazoline in 300 ml. of methanol is added with vigorous stirring, 0.10 mole of 2,3-dihydro-4H-benzopyran-2-carboxylic acid chloride. After the addition is complete, the mixture is stirred for three hours at room temperature and the precipitated title compound is collected by filtration.

Workup

  1. additionAfter the addition
  2. customthe precipitated title compound
  3. filtrationis collected by filtration

Sources & evidence

ORD record
ord-08e69cb881ff405182ce571a94b7fedf
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

Loading…