Acetic Acid → HCID 13060513, compound
Reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](CC)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[O-:12][C:13]#[N:14].[K+].[C:16](O)(=O)[CH3:17]>O>[C:4]([C:3]1[CH:6]=[C:7]([CH2:16][CH3:17])[CH:8]=[CH:9][C:2]=1[NH:1][C:13]([NH2:14])=[O:12])#[N:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-amino-4-ethylbenzonitrile (39.9 g) in acetic acid (200 ml) was added potassium cyanate (24.4 g) under ice-cooling in the course of 15 minutes and stirred overnight in water bath. To the resultant mixture was added water to give precipitates, which were separated by filtration, washed with water and dried at ambient temperature. The resultant crude crystals were recrystallized from ethanol to give crystalline (2-cyano-4-ethylphenyl)urea (29.0 g).
Workup
- temperaturecooling in the course of 15 minutes
- customto give
- customprecipitates
- customwhich were separated by filtration
- washwashed with water
- customdried at ambient temperature
- customThe resultant crude crystals were recrystallized from ethanol
Sources & evidence
- ORD record
- ord-588611f1aff541a68cac883c29b0db67
- Source dataset
- uspto-grants-1983_03
- Patent number
- US04377580
Reaction notes
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