4'-Hydroxypropiophenone → Ifenprodil hydrobromide

Participants

Reaction Steps

To 4 ml of dioxane were added 6.0 g of 4'-hydroxypropiophenone. 6.4 Grams of bromine were added dropwise to the mixture with stirring at room temperature. The reaction liquid was stirred for an additional 5 minutes and then nitrogen gas was introduced thereinto at a flow rate of 400 ml/minute for 10 minutes at 60° C. To the reaction liquid were then added 6.4 g of 4-benzylpyridine and 50 ml of methanol, and the mixture was refluxed under heating for 5 hours. The reaction mixture was then treated in the same manner as described in Example 3, whereby 11.4 g (70.1%) of ifenprodil hydrobromide were obtained as white crystals.

Provenance & Evidence