Bromine → HCID 18940979, compound
Reaction equation
[O:1]=[C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1.[Br:11]Br>C(OCC)C>[Br:11][CH:3]1[CH2:4][CH2:5][C:6]2[CH:7]=[CH:8][O:9][C:10]=2[C:2]1=[O:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 100 ml of diethyl ether, 1.09 g of 7-oxo-4,5,6,7-tetrahydrobenzofuran was dissolved, and 0.41 ml of bromine was added. The mixture was stirred at room temperature for one hour. The solvent was then evaporated, and the residue was subjected to silica gel column chromatography, whereby 1.13 g of 6-bromo-7-oxo-4,5,6,7-tetrahydrobenzofuran was obtained as the oil form from the fraction eluted with hexane-ethyl acetate (10:1).
Workup
- customThe solvent was then evaporated
Sources & evidence
- ORD record
- ord-555e8a6ff7ed4f719f7c6b5b11c6f3ab
- Source dataset
- uspto-grants-1998_11
- Patent number
- US05834499
Reaction notes
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