Ethylamine → 4-bromo-N-ethylthiophene-3-carboxamide
Reaction equation
[Br:1][C:2]1[C:3]([C:7]([OH:9])=O)=[CH:4][S:5][CH:6]=1.[CH2:10]([NH2:12])[CH3:11]>O>[CH2:10]([NH:12][C:7]([C:3]1[C:2]([Br:1])=[CH:6][S:5][CH:4]=1)=[O:9])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
N-Ethyl-4-bromo-3-thiophenecarboxamide was prepared from 4-bromo-3-thiophenecarboxylic acid (7 g, 34 mmol) and 70% ethylamine in water according to steps a and b of Example 248 in 64.5% yield.
Sources & evidence
- ORD record
- ord-8bf33e9d685e4c08b67dc2d3e996617e
- Source dataset
- uspto-grants-1998_11
- Patent number
- US05834447
Reaction notes
Loading…