Ethylamine → N-Ethyl-1-methyl-1H-pyrazole-4-carboxamide

HRID 356449

Reaction equation

HRID 356449 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[CH:4]=[N:3]1.[CH2:10]([NH2:12])[CH3:11]>O>[CH2:10]([NH:12][C:7]([C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1)=[O:9])[CH3:11]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 6431601-Methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 19474722N-Ethyl-1-methyl-1H-pyrazole-4-carboxamideYield 54.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-Ethyl-1-methyl-1H-pyrazole-4-carboxamide was prepared from 1-methyl-1H-pyrazole-4-carboxylic acid and 70% ethylamine in water using the methods of steps a and b of Example 248. The product was purified by flash chromatography with 10% ethyl acetate-hexane and recovered as a white solid in 54.7% yield. m.p. 103°-106° C.

Workup

  1. customThe product was purified by flash chromatography with 10% ethyl acetate-hexane
  2. customrecovered as a white solid in 54.7% yield

Sources & evidence

ORD record
ord-22a62a755d6b46f98bba54c6d713af6c
Source dataset
uspto-grants-1998_11
Patent number
US05834447

Linked notes

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