HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylhydrazinecarbothioamide → N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| Reactant | N-Methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 15595702 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595689 | 30.9% |
Reaction Steps
A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 4.8 g 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 5 hours and treated in similar fashion in Example 67. Chromatography on silica gel with dichloromethane-methanol (96:4) and recrystalization from dichloromethane-hexane afforded 2.1 g yellow crystals, mp 213°-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04767765 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-068f8c38ae0d447b911a6b90870572bf |
| Source note | uspto-grants-1988_08 |