5,11-Dihydro-11-ethyl-5-methyl-2-trifluoromethanesulfonyloxy-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one → 5,11-Dihydro-11-ethyl-2-(1-ethylpyrazol-4-yl)-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Reaction equation
[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[N:6]([CH3:15])[C:5]2[CH:16]=[CH:17][C:18](OS(C(F)(F)F)(=O)=O)=[N:19][C:4]1=2)[CH3:2].[CH2:28]([N:30]1[CH:34]=[C:33](I)[CH:32]=[N:31]1)[CH3:29]>>[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[N:6]([CH3:15])[C:5]2[CH:16]=[CH:17][C:18]([C:33]3[CH:32]=[N:31][N:30]([CH2:28][CH3:29])[CH:34]=3)=[N:19][C:4]1=2)[CH3:2]Participants
3
Procedure
The title compound (a foam, mp 60°-62° C.) was prepared from 5,11-dihydro-11-ethyl-5-methyl-2-trifluoromethanesulfonyloxy-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and N-ethyl-4-iodopyrazole in a manner analogous to that described in Example 1.
Sources & evidence
- ORD record
- ord-7a9f35f14d8741ecaa4bc69245c3d062