Isopropylamine → Propranolol

HRID 35665

Reaction equation

HRID 35665 reaction equation
[CH3:1][CH:2]([NH2:4])[CH3:3].[C:5]1([O:15][CH2:16][CH:17]2[O:19][CH2:18]2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1>O>[CH3:1][CH:2]([NH:4][CH2:18][CH:17]([OH:19])[CH2:16][O:15][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 915212-((1-Naphthalenyloxy)methyl)oxirane

Product 1

HCID 4946Propranolol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.55 ml of (1-methylethyl)amine (0.0297 mol) are mixed with 1.25 ml of H2O and the mixture is then stirred with 5 g of 1-(1-naphthyloxy)-2,3-epoxypropane (0.0249 mol) and reacted at room temperature for 23 hours.

Workup

  1. customreacted at room temperature for 23 hours

Sources & evidence

ORD record
ord-6ecb8913db89475783a4febd207b221b
Source dataset
uspto-grants-1988_08
Patent number
US04767784

Linked notes

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