HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,4-Dichlorobenzyl chloride | HCID 7212 | — |
| Reactant | 4-Amino-2-chlorobenzoic acid | HCID 17154 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid | HCID 21836975 | — |
Reaction Steps
To a stirred mixture of 5.19 g of 2-chloro-4-aminobenzoic acid in 150 ml of methylene chloride is added 7.86 g of N,N-diisopropylethylamine and 12.67 g of 2,4-dichlorobenzylchloride and stirring continued for 18 hours. Water is added to the filtrate and the organic layer dried with Na2 SO4 and concentrate in vacuo to give 13.68 g of the desired product, m.p. 171°-175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733905 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-1da5671a1bbe46e789d3388e15982cfa |
| Source note | uspto-grants-1998_03 |