Methanol → 1-Methyl-3,5-diphenylpyrazole

HRID 357528

Reaction equation

[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18]O>>[CH3:18][N:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:11][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:9]1

Participants

Reactant 2

HCID 887Methanol

HCID 708401H-Pyrazole, 3,5-diphenyl-

Product 1

HCID 1405171-Methyl-3,5-diphenylpyrazoleYield 91%

Procedure

A total of 181.5 g (0.825 mol) of 3,5-diphenylpyrazole and 791 g (24.7 mol) of methanol was used. A total of 175.8 g (91%) of 1-methyl- 3,5-diphenylpyrazole was obtained. The holdup of the bubble column was not taken into account.

Sources & evidence

ORD record: ord-78cf8971f53a467a8ff0bc6babcc370a
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05840913

Linked notes

Loading…