Methyl isothiocyanate → HCID 178486097, compound
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[CH3:13][N:14]=[C:15]=[S:16]>C(O)C>[CH3:13][NH:14][C:15]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1)=[S:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2.3 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.15 gm of methyl isothiocyanate in 30 ml of ethanol was refluxed for thirty minutes and evaporated to dryness. The oily base so obtained was purified by conversion into the corresponding hydrochloride salt by bubbling gaseous hydrochloric acid in isopropanol. The desired thiourea was obtained as a white solid.
Workup
- customevaporated to dryness
- customThe oily base so obtained
- customwas purified by conversion into the corresponding hydrochloride salt
- customby bubbling gaseous hydrochloric acid in isopropanol
Sources & evidence
- ORD record
- ord-3b6a72acc242468fa129b70ab27e32a6
- Source dataset
- uspto-grants-1984_08
- Patent number
- US04465841
Reaction notes
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