Diazomethane → 3-Hexynoic acid methyl ester
Reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][C:3]#[C:4][CH2:5][CH3:6].[N+](=[CH2:11])=[N-]>CCOCC.C(O)(=O)C>[CH3:11][O:7][C:1](=[O:8])[CH2:2][C:3]#[C:4][CH2:5][CH3:6]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 5.9 g of 3-hexynoic acid in 50 ml of ether is treated with a slight excess of ethereal diazomethane solution. A few drops of glacial acetic acid are added to the mixture, the mixture is concentrated in vacuo and then distilled. 5.65 g of the title compound are obtained: b.p. 62° C. (5 mm).
Workup
- concentrationthe mixture is concentrated in vacuo
- distillationdistilled
Sources & evidence
- ORD record
- ord-f9726011908648edaaa2665197868482
- Source dataset
- uspto-grants-1984_08
- Patent number
- US04466969
Reaction notes
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